LATE-LIFE DEPRESSION & ALZHEIMER’S DISEASE: A PROPOSAL FOR THE BI-DIRECTIONAL THRESHOLD MODEL.

Lieke michaela Hoekman

Abstract


Until now, the relationships between late-life depression and Alzheimer’s Disease (AD) and vice versa have only been investigated in terms of one-directional relationships. However, due to the central neuropathological mechanisms underlying both diseases, it is proposed that the interaction is bi-directional. These mechanisms include the stress-response hypothesis, amyloid hypothesis, inflammatory hypothesis, and genetic hypothesis. By reviewing these shared underlying mechanisms, as well as investigating the evidence for both one-directional relationships, a new model is proposed, namely the bi-directional threshold model. Whereas previous research only focused on one-directional interaction, this model is novel in accounting for the bi-directional interaction between AD and late-life depression. Thereby the model contributes to the literature on late-life depression and AD by serving as a starting point for further research. A better understanding of this new model could have major implications in ameliorating the course of both clinical conditions.

Keywords


Alzheimer’s disease, late-life depression, bi-directional relationship, proposal for bi-directional threshold model.

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DOI: http://dx.doi.org/10.26481/mjla.2018.v10.624

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