Decisive mechanism for selectively inducing NMDAR-dependent LTP versus LTD: The role of Ca2+ influx

Authors

  • Kim Hoffmann

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) are two types of synaptic plasticity. Interestingly, NMDAR-dependent LTP and LTD are induced by Ca2+ influx into the post-synaptic cell. This raises the question how the cell selectively induces either LTP or LTD. Early research suggested Ca2+ amplitude as a decisive mechanism. This essay critically evaluates this hypothesis by reviewing evidence and alternative candidates (i.e., timing/location of Ca2+ influx, NMDAR subunits, competition between AMPAR exocytosis/endocytosis). In sum, the amplitude of Ca2+ influx should be seen as one of many components entailed in the complex decisive machinery for selective LTP and LTD induction.

Maastricht Student Journal of Psychology and Neuroscience, edition 10

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Published

2023-09-01

Issue

Vol. 10 No. 1 (2023): Maastricht Student Journal of Psychology and Neuroscience

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Articles

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